| POTUS: | Joe Biden |
| FLOTUS: | Dr. Jill Tracy Biden |
| Vice President: | Kamala Devi Harris |
| Agriculture Secretary: | Tom Vilsack |
| Attorney General: | Merrick Garland |
| CIA Director: | William J. Burns |
| Commerce Secretary: | Gina Raimondo |
| Defense Secretary: | Lloyd J. Austin III |
| Economic Advisors Council Chair: | Dr. Cecilia Rouse |
| Education Secretary: | Dr. Miguel Cardona |
| Energy Secretary: | Jennifer Granholm |
| EPA Administrator: | Michael Regan |
| Health and HS Secretary: | Xavier Becerra |
| Homeland Security Secretary: | Alejandro Mayorkas |
| HUD Secretary: | Marcia Fudge |
| Interior Secretary: | Debra Haaland |
| Labor Secretary: | Marty Walsh/Julie Su, Acting |
| National Intelligence Director: | Avril Haines |
| National Security Advisor: | Jake Sullivan |
| OMB Director: | Shalanda D. Young |
Science Advisor/
Office of Science and Technology Director: | Dr. Eric Lander/Dr. Arati Prabhakar |
| Secretary of State: | Antony J. Blinken |
| SEC Chair: | Gary Gensler |
| Small Business Administration Administrator: | Isabel Guzman |
| Transportation Secretary: | Pete Buttigieg |
| Treasury Secretary: | Dr. Janet Yellen |
| United Nations Ambassador: | Linda Thomas-Greenfield |
| Deputy US Trade Representative: | Katherine Tai |
| Veterans Affairs Secretary: | Denis McDonough |
| White House Chief of Staff: | Ron A. Klain/Jeff Zients |
| White House National Climate Advisor: | Gina McCarthy/Ali Zaidi |
| White House Legislative Affairs Advisor: | Jonathan Black/Louisa Terrell |
| White House Press Secretary: | Jen Psaki/Karine Jean-Pierre |